Ch. Tran et al., SYNTHESIS OF (-)-6-HYDROXYSHIKIMIC ACID FROM )-5,6-DIHYDROXY-1,3-CYCLOHEXADIENYL)METHANENITRILE, Tetrahedron : asymmetry, 7(3), 1996, pp. 691-698
A six step synthesis of (-)-6-hydroxyshikimic acid 2 has been develope
d starting from R)-5,6-dihydroxy-1,3-cyclohexadienyl)methanentrile 3,
produced by biotransformation of cyanobenzene by the enzyme toluene di
oxygenase. (C) 1996 Elsevier Science Ltd