DELAYED GENERALIZATION TESTING PRODUCES ENHANCED ALCOHOL AVERSIONS INRATS

Citation
Te. Thiele et al., DELAYED GENERALIZATION TESTING PRODUCES ENHANCED ALCOHOL AVERSIONS INRATS, Alcohol, 13(2), 1996, pp. 201-207
Citations number
24
Categorie Soggetti
Substance Abuse","Pharmacology & Pharmacy",Toxicology
Journal title
ISSN journal
07418329
Volume
13
Issue
2
Year of publication
1996
Pages
201 - 207
Database
ISI
SICI code
0741-8329(1996)13:2<201:DGTPEA>2.0.ZU;2-G
Abstract
Three experiments examined the effects of the training-to-testing inte rval on alcohol aversions. In Experiments 1 and 2, rats learned a tast e aversion to a 4% (v/v) alcohol solution using lithium chloride as th e illness agent. With a between-groups design, subjects were tested wi th 1%, 4%, or 7% alcohol, beginning either 2 or 21 days after training . In both experiments, results showed that rats learned aversions to t he trained 4% alcohol that generalized to the nontrained 1% and 7% con centrations. Furthermore, in Experiment 1 aversions to 1% and 7% alcoh ol were stronger in groups tested 21 days after training relative to g roups tested 2 days after training. When the strength of the illness a gent was reduced in Experiment 2, aversions to all concentrations of a lcohol were stronger at the delayed testing interval. Experiment 3 rul ed out the possibility that enhanced alcohol avoidance at delayed test ing was the result of spontaneous recovery of neophobia. The results s uggest that taste aversions to alcohol become stronger with time. Poss ible mechanisms for this ''incubation effect'' are discussed. The pres ent findings have implications for improving emetic therapy as a treat ment for human alcoholics.