AN EFFICIENT STEREOCONTROLLED SYNTHESIS OF METHYL (9Z,11E,13S)-13-HYDROXYOCTADECA-9,11-DIENOATE (METHYL CORIOLATE)

Authors
CHEMIN D LINSTRUMELLE G
Citation
D. Chemin et G. Linstrumelle, AN EFFICIENT STEREOCONTROLLED SYNTHESIS OF METHYL (9Z,11E,13S)-13-HYDROXYOCTADECA-9,11-DIENOATE (METHYL CORIOLATE), Synthesis, (4), 1993, pp. 377-379
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
4
Year of publication
1993
Pages
377 - 379
Database
ISI
SICI code
0039-7881(1993):4<377:AESSOM>2.0.ZU;2-G
Abstract
An efficient synthesis of methyl (13S)-coriolate (S)-1b is accomplishe d by the palladium-catalyzed coupling of (1E,3S)-1-iodooct-1-en-3-ol [ (S)-3] with methyl dec-9-ynoate (4) followed by selective reduction of the enyne (S)-2.