PHARMACOKINETICS OF C-14 -N'-DICYCLOPROPYL-METHYL-PIPERAZINE-DICHLORHYDRATE - 2ND COMMUNICATION - TISSUE DISTRIBUTION IN RATS

Authors
ATABAKHSH F BENARD P DECLUME C TUFENKJI AE MALBOSC R CAMPISTRON G HOUIN G
Citation
F. Atabakhsh et al., PHARMACOKINETICS OF C-14 -N'-DICYCLOPROPYL-METHYL-PIPERAZINE-DICHLORHYDRATE - 2ND COMMUNICATION - TISSUE DISTRIBUTION IN RATS, Arzneimittel-Forschung, 43-1(4), 1993, pp. 436-440
Citations number
4
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
43-1
Issue
4
Year of publication
1993
Pages
436 - 440
Database
ISI
SICI code
0004-4172(1993)43-1:4<436:POC->2.0.ZU;2-E
Abstract
The distribution of radioactivity in rats after intravenous or oral ad ministration of C-14-labelled N-N'-di-cyclopropyl-methyl-piperazine di chlorhydrate (C-14-Ino 2628-CZ) demonstrated that the labelled compoun d was widely distributed in the body. An important diffusion of the is otope was found in the central nervous system, the gastric mucosa and several glands. Only small amounts of radioactivity were found in thes e organs 24 h after dosage.