As the route of breathing and use of airway apparatus such as mask, mo
uthpiece and noseclip can alter breathing pattern, this study has used
the helium dilution method to estimate the effects of mouthpiece and
mask breathing on functional residual capacity (FRC) in the supine pos
ition, and the change in FRC that occurs between the sitting and supin
e positions while breathing by mouthpiece. In 13 normal subjects, brea
thing by mouthpiece, FRC was smaller, by a median of 1.07 litre (inter
quartile values 0.73-1.43 litre) in the supine compared with the sitti
ng position (P < 0.01), but residual volume (RV) did not change signif
icantly. FRC measured in the supine position was significantly greater
when breathing by mask than by mouthpiece (0.25, 0.04-0.38 litre) and
RV was greater by similar amounts (0.20, -0.02 to 0.49 litre). This d
ifference may result from increased inspiratory activity while breathi
ng via the mask.