SYNTHESIS OF NEW 5-SUBSTITUTED PYRAZOLO[1,5-D][1,2,4]-TRIAZINE DERIVATIVES AND THEIR ANALGESIC, ANTIINFLAMMATORY AND ANTIPYRETIC PROPERTIES

A series of 2-aryl-4-oxo-pyrazolo[1,5-d][1,2,4]triazines substituted i n the 5-position by aminoalkyl or benzoyl moieties was synthesized and evaluated for analgesic activity. The structures of new triazine deri vatives were confirmed by IR, H-1-NMR spectra and by elementary analys is. In the phenylbenzoquinone induced writhing test, only 3,3a-dihydro pyrazolo triazines substituted by an arylpiperazinylmethyl group exhib ited potent analgesic effect. In addition, these compounds possessed s ignificant anti-inflammatory and antipyretic properties. A desaturatio n in 3,3a positions or other groups than arylpiperazinylmethyl moietie s notably decreased analgesic effects.