TRANSCUTANEOUS ABSORPTION OF NONSTEROIDAL ANTIRHEUMATIC DRUGS - CLINICAL-STUDY WITH A NEW MODEL FOR THE INVESTIGATION OF PHARMACOKINETICS

Transcutaneous Absorption of Non-steroidal Antirheumatic Drugs / Clini cal study with a new model for the investigation of pharmacokinetics T he feasibility of the bilateral vein stripping model for the investiga tion of the transcutaneous absorption of a non-steroisal antirheumatic drug (NSAID) was examined. After application of a 1% solution of indo metacin (Elmetacin(R), CAS 53-86-1) at one leg (steady state) plasma a nd vein tissue of both sides was taken at the same time. The mean indo metacin plasma levels of 19 female patients were 7 ng/ml, in the vein tissue of the application side 280 ng/g and at the opposite side 80 ng /g The tissue levels in the veins are in the same range as in the targ et tissues of transcutaneous antirheumatic therapy. Therefore the mode l is considered useful for the investigations of the pharmacokinetics of topically applied NSAID.