SYNTHESIS AND ANTIPARASITIC ACTIVITY OF NEW 1-NITRO, 1-AMINO AND 1-ACETAMIDO 9-ACRIDINONES

Authors
NGADI L BSIRI NG MAHAMOUD A GALY AM GALY JP SOYFER JC BARBE J PLACIDI M RODRIGUEZSANTIAGO JI MESAVALLE C LOMBARDO R MASCARO C OSUNA A
Citation
L. Ngadi et al., SYNTHESIS AND ANTIPARASITIC ACTIVITY OF NEW 1-NITRO, 1-AMINO AND 1-ACETAMIDO 9-ACRIDINONES, Arzneimittel-Forschung, 43-1(4), 1993, pp. 480-483
Citations number
27
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
43-1
Issue
4
Year of publication
1993
Pages
480 - 483
Database
ISI
SICI code
0004-4172(1993)43-1:4<480:SAAAON>2.0.ZU;2-V
Abstract
The synthesis of 1-amino-10-alkyl-9-acridinones 4 and 5 and of homolog ous 9-thio-acridinones 7 and 8 are described Similarly, the synthesis of 1-nitro-4-(2'-aminoethylamino)-9-acridinones 13 and 15, is describe d. Compound 4 was used as starting material for the preparation of 10- alkyl-9-acridinone dimers 6, bridged with an alpha,omega-diamido chain . Compound 15 was selected for biological investigations on pathogenic parasite strains, and a promising antiamoebic activity could be shown .