ADVERSE-EFFECTS OF KETOPROFEN AFTER INTRA UTERINE EXPOSURE - PROGNOSTIC VALUE OF ITS MEASUREMENT IN PLASMA

Background.-Prostaglandin synthetase inhibitors have been used to prev ent the onset of premature labor. But a small number of newborn infant s have been reported with premature closure of the ductus arteriosus, pulmonary hypertension and/or oliguria. Population and methods.-Eleven neonates for seven pregnancies were admitted because they suffered fr om adverse effect of ketoprofen given to their mothers before delivery . The plasma ketoprofen level was measured in 6 of the neonates.Result s.-Ten of the 11 neonates had renal dysfunction which was lethal in th ree; two of the 11 developed cardiopulmonary complications, lethal in one. The ketoprofen concentration in plasma was high in the first few hours of life in three patients. Conclusion.-In the absence of precise risk factors for prognosis, repeated drug measurements in the materna l plasma before delivery and in their babies after birth could be a pr edictive factor.