If periodontal disease is due to a limited number of bacterial species
, then continuous maximal plaque suppression is not the only possibili
ty for prevention and therapy Specific elimination or reduction of pat
hogenic bacteria from plaque becomes a valid alternative. Recent studi
es indicate that the elimination of certain putative pathogens is part
icularly difficult. New diagnostic methods should allow the choice of
better suited procedures, make chosen procedures more effective (throu
gh better timing, dosage, selection of devices or drugs, increase of s
pecificity, etc.) or lead to the elimination of unnecessary work (e.g.
, the treatment of non-susceptible sites or patients). The benefit of
newly proposed tests depends on the possible impact of the obtained in
formation on clinical decisions and on the consequences these decision
s have for treatment. Thus, diagnostic methods and therapeutical optio
ns have to be evaluated together.