THIAMINE, RIBOFLAVIN, FOLATE, AND VITAMIN-B-12 STATUS OF INFANTS WITHLOW BIRTH WEIGHTS RECEIVING ENTERAL NUTRITION

The purpose of the present study was to monitor the vitamin status of 14 low-birth-weight (LBW) infants (<1,750 g birth weight) at 2 weeks a nd an additional four infants at 3 weeks who were receiving an enteral formula providing 247 mu g/100 kcal thiamine, 617 mu g/100 kcal ribof lavin, 37 mu g/100 kcal folate, and 0.55 mu g/100 kcal vitamin B-12. T he mean birth weight of the 18 infants was 1,100 +/- 259 g, and mean g estational age was 29 +/- 2 weeks. Weekly blood, 24-h urine collection s, and dietary intake data were obtained. For thiamine, red blood cell (RBC) transketolase activity was within the normal range for all infa nts. For riboflavin, RBC glutathione reductase activity was normal for all infants except one. We calculated from intake and urinary excreti on data that these infants require 225 mu g/100 kcal thiamine and 370 mu g/100 kcal riboflavin, respectively. Mean plasma folate levels were 21 +/- 11 ng/ml at 2 weeks and 18 +/- 5 ng/ml at 3 weeks. RBC folate levels were 455 +/- 280 ng/ml at 2 weeks and 391 +/- 168 ng/ml at 3 we eks. All folate blood values were normal, except for one subject with an elevated level (59 ng/ml). Vitamin B-12 plasma values were 737 +/- 394 pg/ml at 2 weeks and 768 +/- 350 pg/ml at 3 weeks, and all values were normal except for three infants with elevated values. In conclusi on, appropriate vitamin status was maintained during this short observ ational period, during administration of this enteral formula; however , riboflavin concentrations in the enteral feed may be excessive.