2-BUTEN 4-OLIDE AFFECTS FEEDING-BEHAVIOR OF RHESUS-MONKEY

1. Endogenous satiety substance 2-Buten 4 Olide (2-B40- a short chain sugar derivative) effect on feeding behaviour of rhesus monkey was stu died. 2. The cannula was implanted in the third ventricle of three, ad ult, male, rhesus monkeys. 3. Monkeys were conditioned to ingest their daily requirement of food during one hour. 4. Their daily food intake was recorded. 5. Various doses of 2-B40 (1.6, 2.1, 2.7, 4.3, 10.6, 20 and 25 mg) were administered intracerebroventricularly on different d ays five minutes prior to presentation of food. 6. The effective dose for inducing significant satiety effect was 20.0 mg,while 10.6 mg indu ced a mild and 25.0 mg a severe effect. 7. However, when administered intraperitoneally 43 mg/kg bw 2-B40 induced satiety effect, but was in effective in doses of 1.5 to 21.5 mg bw. 8. This study is suggestive o f the presence of 2-B40 satiety mechanism in monkeys almost in doses s imilar to those previously reported for rats.