ACUTE-BRAIN-SYNDROME AFTER TAPERING OFF CLOZAPINE IN CLOZAPINE-LITHIUM COMBINATION

1. This is a report of a patient who developed an acute organic psycho sis due to neurotoxicity of lithium several days after tapering off a long-lasting clozapine therapy. 2. The organic brain syndrome with ini tial illusionary misperceptions, a confusional state and a lapse into a pre-coma developed three days after the end of clozapine therapy and seven days after the beginning of haloperidol addition.3. Possible ph armacokinetic and pharmacodynamic factors responsible for the severe n eurotoxicity of lithium after withdrawal of clozapine and addition of haloperidol are discussed.