COMPARATIVE EFFECT OF NIFEDIPINE AND S-ADENOSYLMETHIONINE, SINGLY ANDIN COMBINATION ON EXPERIMENTAL RAT-LIVER CIRRHOSIS

Authors
BARRIO E CUTRIN C MENINO MJ PEREZBECERRA E
Citation
E. Barrio et al., COMPARATIVE EFFECT OF NIFEDIPINE AND S-ADENOSYLMETHIONINE, SINGLY ANDIN COMBINATION ON EXPERIMENTAL RAT-LIVER CIRRHOSIS, Life sciences, 52(20), 1993, pp. 217-220
Citations number
22
Categorie Soggetti
Biology,"Medicine, Research & Experimental
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
52
Issue
20
Year of publication
1993
Pages
217 - 220
Database
ISI
SICI code
0024-3205(1993)52:20<217:CEONAS>2.0.ZU;2-F
Abstract
An experimental rat liver cirrhosis, by means of carbon tetrachloride and ethanol during 8 weeks, was employed to assay the effect of Nifedi pine (a calcium antagonist blocker), S-Adenosylmethionine (a precursor of glutathione); singly and in combination on rat liver cirrhosis. A slight decrease of cirrhosis (N.S.) was observed with the pharmacologi cal therapy employed singly. The combination therapy (Nifedipine+S-Ade nosylmethionine) significantly inhibited liver cirrhosis (p<0.01).