ECTOPIC INDUCTION OF CARTILAGE AND BONE BY BOVINE BONE MORPHOGENETIC PROTEIN USING A BIODEGRADABLE POLYMERIC RESERVOIR

Authors
YAMAZAKI Y OIDA S ISHIHARA K NAKABAYASHI N
Citation
Y. Yamazaki et al., ECTOPIC INDUCTION OF CARTILAGE AND BONE BY BOVINE BONE MORPHOGENETIC PROTEIN USING A BIODEGRADABLE POLYMERIC RESERVOIR, Journal of biomedical materials research, 30(1), 1996, pp. 1-4
Citations number
26
Categorie Soggetti
Engineering, Biomedical","Materials Science, Biomaterials
Journal title
Journal of biomedical materials research → ACNP
ISSN journal
00219304
Volume
30
Issue
1
Year of publication
1996
Pages
1 - 4
Database
ISI
SICI code
0021-9304(1996)30:1<1:EIOCAB>2.0.ZU;2-B
Abstract
Two kinds of bone morphogenetic protein (BMP) containing polymeric res ervoirs made from poly(lactide-coglycolide) (PLG) and a mixture of PLG /poly(ethylene glycol) (PEG) (PLG/PEG) were implanted into mice femora l muscles. In the PLG/PEG reservoir with BMP, bone formation was induc ed within 3 weeks. On the other hand, in the PLG reservoir with BMP sc arcely any bone formation could be observed. The results suggest that the carrier system is most important for the development of BMP-induce d bone formation and the PLG/PEG reservoir system is available for BMP delivery. (C) 1996 John Wiley & Sons, Inc.