TIN(IV)-FUNCTIONALIZED POLYMER SUPPORTS - NONTOXIC AND PRACTICAL REAGENTS FOR REGIOSELECTIVE ACETYLATION OF SUCROSE

Polymer-supported butyltin(IV) reagents have been surveyed for regiose lectivity in acetylation of sucrose. Polymer-supported butyltin(IV) di chloride 8 catalysed the acetylation of sucrose to give a 59% yield of 6-O-acetyl sucrose 3, the precursor of sucralose. The yield is close to that of a previously reported process involving dibutyltin(IV) oxid e (Bu(2)SnO). The spent polymeric resin could readily be regenerated a nd can be subsequently used in further synthetic reactions.