HELICOBACTER-PYLORI INFECTION IN PATIENTS WITH GASTRIC ADENOCARCINOMA

We examined the biologic tumor behavior in Helicobacter pylori-seropos itive patients with gastric adenocarcinoma. A total of 214 consecutive patients with pathologically confirmed adenocarcinoma of the stomach who underwent gastric resection were studied. The stored serum samples were tested for serum antibody to H. pylori by using a highly sensiti ve and specific IgG enzyme-linked immunosorbent assay. The difference in H. pylon-seropositive and seronegative patients with gastric adenoc arcinoma was evaluated in terms of various clinicopathologic parameter s, A multivariate logistic regression analysis was used to adjust for potential confounding variables; Antibodies to H. pylori were detected in 65.9% of patients with gastric adenocarcinoma. H. pylori-seroposit ive patients were younger than seronegative patients and had infiltrat ive tumor according to Ming's criteria. When adjusted for age, infiltr ative tumor come out stronger, These findings suggest that H. pylori i nfection may be related to infiltrative type gastric adenocarcinoma; f urther study is necessary.