Tw. Wehbe et Ja. Warth, A CASE OF BLEEDING REQUIRING HOSPITALIZATION THAT WAS LIKELY CAUSED BY AN INTERACTION BETWEEN WARFARIN AND LEVAMISOLE, Clinical pharmacology and therapeutics, 59(3), 1996, pp. 360-362
Warfarin is one of the most commonly used oral anticoagulants, Many me
dications have been shown to influence the prothrombin time in patient
s treated with warfarin by various mechanisms, We observed a major ble
eding episode that resulted from a probable interaction between levami
sole (Ergamisol), 5-fluorouracil, and warfarin, It is conceivable that
many patients who are predisposed to thromboembolism because of cance
r and surgery will be taking this combination of medications.