SYNTHESIS, STRUCTURE AND ANTIAGGREGATORY EFFECTS OF SOME ALPHA-HYDROXY ANALOGS OF 2-ARYLIMINOIMIDAZOLINES IN HUMAN PLATELETS

Authors
SACZEWSKI F DEBOWSKI T GDANIEC M PETRUSEWICZ J TUROWSKI M DAMASIEWICZ B
Citation
F. Saczewski et al., SYNTHESIS, STRUCTURE AND ANTIAGGREGATORY EFFECTS OF SOME ALPHA-HYDROXY ANALOGS OF 2-ARYLIMINOIMIDAZOLINES IN HUMAN PLATELETS, European journal of pharmaceutical sciences, 4(2), 1996, pp. 85-93
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmaceutical sciences → ACNP
ISSN journal
09280987
Volume
4
Issue
2
Year of publication
1996
Pages
85 - 93
Database
ISI
SICI code
0928-0987(1996)4:2<85:SSAAEO>2.0.ZU;2-Z
Abstract
Title compounds 3a-i were obtained from the reaction of 2-chloro-4,5-d ihydroimidazole 1 and suitable N-arylhydroxylamines 2. Crystal and mol ecular structure of the 3-methyl derivative 3b was determined. To gain an understanding of the significance of alpha-hydroxy group in the 2- aryl-iminoimidazolines, compounds 3a-i were studied as potential inhib itors of the blood platelet aggregation induced by adrenaline.