CHOLECYSTOKININ (CCK) AND C-TERMINAL FRAGMENTS OF CCK - EFFECTS OF CCK-33, CCK-8 AND CCK-4 IN THE CARDIOVASCULAR-SYSTEM OF DIABETIC RATS

Authors
WISNIEWSKA RJ WISNIEWSKI K
Citation
Rj. Wisniewska et K. Wisniewski, CHOLECYSTOKININ (CCK) AND C-TERMINAL FRAGMENTS OF CCK - EFFECTS OF CCK-33, CCK-8 AND CCK-4 IN THE CARDIOVASCULAR-SYSTEM OF DIABETIC RATS, General pharmacology, 27(2), 1996, pp. 399-405
Citations number
41
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
27
Issue
2
Year of publication
1996
Pages
399 - 405
Database
ISI
SICI code
0306-3623(1996)27:2<399:C(ACFO>2.0.ZU;2-M
Abstract
The effect of cholecystokinin (CCK-33) and its fragments, CCK-8 and CC K-4, on arterial blood pressure and the function of isolated rat heart and catecholamine levels in plasma and from isolated heart tissue in diabetes mellitus were studied. The results indicated that, in diabete s, cardiovascular effects of CCK-33 and CCK-8 are diminished or abolis hed. Diabetes can change the response of the alpha- and beta-adrenergi c system to CCK-33 and CCK-8 and the contents of catecholamines in hea rt tissue.