DIFFERENTIAL REGULATION OF THE MCB AND EMR OPERONS OF ESCHERICHIA-COLI - ROLE OF MCB IN MULTIDRUG-RESISTANCE

Authors
LOMOVSKAYA O KAWAI F MATIN A
Citation
O. Lomovskaya et al., DIFFERENTIAL REGULATION OF THE MCB AND EMR OPERONS OF ESCHERICHIA-COLI - ROLE OF MCB IN MULTIDRUG-RESISTANCE, Antimicrobial agents and chemotherapy, 40(4), 1996, pp. 1050-1052
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
4
Year of publication
1996
Pages
1050 - 1052
Database
ISI
SICI code
0066-4804(1996)40:4<1050:DROTMA>2.0.ZU;2-X
Abstract
The mcb operon (which is responsible for microcin B17 production) and the emr operon (which encodes a multidrug resistance pump) share a com mon negative regulator, EmrR. Nevertheless, compounds that induce the emr operon repress the mcb operon, The pump dedicated to microcin B17 extrusion can also protect the cells against sparfloxacin and other to xic compounds.