Ak. Chakraborty et al., HYDROQUINONE SIMULTANEOUSLY INDUCES INDOLE AMINE-2,3 DIOXYGENASE (IOD) AND INHIBITS TYROSINASE IN BUFO-MELANOSTICTUS, Life sciences, 52(21), 1993, pp. 1695-1698
Hydroquinone administration in Bufo melanostictus causes an induction
of indole amine 2,3-dioxygenase in skin and liver while simultaneously
inhibiting tyrosinase in these organs. The result is discussed with t
he reports of higher urinary excretion of abnormal indole metabolites
including derivatives of anthranilic acid in vitiliginous subjects (Ro
ychoudhury and Chakraborty, Clinica. Chim. Acta 22, 298, 1968; Kurbano
v and Berezov, Vopr. Med. Khim. 22, 683, 1976).