HYDROQUINONE SIMULTANEOUSLY INDUCES INDOLE AMINE-2,3 DIOXYGENASE (IOD) AND INHIBITS TYROSINASE IN BUFO-MELANOSTICTUS

Authors
CHAKRABORTY AK CHAKRABORTY A CHAKRABORTY DP
Citation
Ak. Chakraborty et al., HYDROQUINONE SIMULTANEOUSLY INDUCES INDOLE AMINE-2,3 DIOXYGENASE (IOD) AND INHIBITS TYROSINASE IN BUFO-MELANOSTICTUS, Life sciences, 52(21), 1993, pp. 1695-1698
Citations number
21
Categorie Soggetti
Biology,"Medicine, Research & Experimental
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
52
Issue
21
Year of publication
1993
Pages
1695 - 1698
Database
ISI
SICI code
0024-3205(1993)52:21<1695:HSIIAD>2.0.ZU;2-Z
Abstract
Hydroquinone administration in Bufo melanostictus causes an induction of indole amine 2,3-dioxygenase in skin and liver while simultaneously inhibiting tyrosinase in these organs. The result is discussed with t he reports of higher urinary excretion of abnormal indole metabolites including derivatives of anthranilic acid in vitiliginous subjects (Ro ychoudhury and Chakraborty, Clinica. Chim. Acta 22, 298, 1968; Kurbano v and Berezov, Vopr. Med. Khim. 22, 683, 1976).