PROSTAGLANDIN-H SYNTHASE-DEPENDENT FORMATION OF THE DIRECT-ACTING MUTAGEN 2-NITRO-3-METHYLIMIDAZO[4,5-F]QUINOLINE (NITRO-IQ) FROM IQ

Authors
MORRISON LD ELING TE JOSEPHY PD
Citation
Ld. Morrison et al., PROSTAGLANDIN-H SYNTHASE-DEPENDENT FORMATION OF THE DIRECT-ACTING MUTAGEN 2-NITRO-3-METHYLIMIDAZO[4,5-F]QUINOLINE (NITRO-IQ) FROM IQ, MUTATION RESEARCH, 302(1), 1993, pp. 45-52
Citations number
32
Categorie Soggetti
Genetics & Heredity",Toxicology
Journal title
MUTATION RESEARCH → ACNP
ISSN journal
00275107
Volume
302
Issue
1
Year of publication
1993
Pages
45 - 52
Database
ISI
SICI code
0027-5107(1993)302:1<45:PSFOTD>2.0.ZU;2-8
Abstract
The mutagenic effects of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) following activation by ram seminal vesicle microsomes (RSVM, a source of prostaglandin H synthase, PHS) were studied in Salmonella typhimur ium tester strains possessing elevated levels of acetyl-CoA : arylamin e N-acetyltransferase (NAT). The metabolites formed by RSVM were extra cted and fractionated by high pressure liquid chromatography (HPLC). O ne isolable product accounted for most of the direct-acting mutagenici ty observed in the extracts. The metabolite was identified as 2-nitro- 3-methylimidazo[4,5-f]quinoline (nitro-IQ). Since nitro-IQ is a potent direct-acting mutagen, its role in IQ genotoxicity warrants further s tudy.