INTERLEUKIN-10 PHARMACOKINETICS IN INTACT AND NEPHRECTOMIZED MICE

The influence of kidney function on interleukin-10 (IL-10) pharmacokin etics was assessed by comparing the disappearance of IL-10 from the ci rculation in the intact and acutely nephrectomized mice over 1 h follo wing a single bolus injection of E, coli-derived recombinant h IL-10 a t 250 mu g/kg i.v. The intact mice demonstrated a C-max of 1,172 ng/ml and an AUC((tf)) of 385 ng . h/ml. By comparison, there was a 4-fold elevation in C-max and a 7-fold increase in AUC((tf)) in the anephric mice, The serum IL-10 concentration at 1 h post-injection was 87 ng/ml in the intact vs 1,684 ng/ml in the anephric mice, The results imply that IL-10, in common with other cytokines, is eliminated through the kidney.