CHROMATOGRAPHIC DETERMINATION OF THE RADIOCHEMICAL PURITY OF [I-131] METAIODOBENZYLGUANIDINE INFUSION FLUIDS - A COMPARISON AND DISCUSSION OF THE CHROMATOGRAPHIC CHARACTERISTICS USING 3 DIFFERENT TECHNIQUES

Authors
WAFELMAN AR HOEFNAGEL CA BEIJNEN JH
Citation
Ar. Wafelman et al., CHROMATOGRAPHIC DETERMINATION OF THE RADIOCHEMICAL PURITY OF [I-131] METAIODOBENZYLGUANIDINE INFUSION FLUIDS - A COMPARISON AND DISCUSSION OF THE CHROMATOGRAPHIC CHARACTERISTICS USING 3 DIFFERENT TECHNIQUES, Applied radiation and isotopes, 44(5), 1993, pp. 859-867
Citations number
29
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging
Journal title
Applied radiation and isotopes
ISSN journal
09698043 → ACNP
Volume
44
Issue
5
Year of publication
1993
Pages
859 - 867
Database
ISI
SICI code
0969-8043(1993)44:5<859:CDOTRP>2.0.ZU;2-A
Abstract
This paper proposes a reproducible and validated assay based on solid phase extraction for the determination of the level of free [I-131]iod ide in [I-131]metaiodobenzylguanidine infusion fluids. The method has been compared with HPLC and TLC assays. Furthermore, a TLC system is i ntroduced that allows the separation between metaiodobenzylguanidine, its chemical precursor metaiodobenzylamine and iodide. Attention is pa id to the chromatographic characteristics of the analytes, with a disc ussion of the possible retention mechanisms.