S. Stoneelander et N. Elander, FAST CHEMISTRY IN MICROWAVE FIELDS - NUCLEOPHILIC F-18 RADIOFLUORINATIONS OF AROMATIC-MOLECULES, Applied radiation and isotopes, 44(5), 1993, pp. 889-893
Citations number
37
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging
Nucleophilic aromatic radiofluorinations with [F-18]fluoride in a micr
owave field were investigated in activated, partially deactivated and
deactivated aromatic compounds. A coaxial resonance microwave cavity w
as used to produce a well-defined electromagnetic field in the samples
. The leaving group on the aromatic rings as well as the ortho, meta a
nd para orientation of electron-withdrawing and electron-donating subs
tituents were varied. Yields comparable to or better than those report
ed for thermal treatments were obtained in very short reaction times (
less-than-or-equal-to 0.5 min, i.e. 1/20th-1/40th the thermal times) w
ith very low microwave intensity and followed the trend of reactivity
expected from the substrates activation for nucleophilic substitution.