Paleomolecular biochemistry is a new field of science that seeks to un
derstand how life emerged and developed in interaction with its geophy
sical surroundings. It is an experimental science, involving reconstru
ction of extinct biomolecules in the laboratory, studying their proper
ties in the laboratory, and inferring details of their behavior and fu
nction in the context of geological data. An outline is provided of so
me tools of this field, together with its application to the study of
two specific systems, ribonuclease and alcohol dehydrogenase.