TROUGH PEAK RATIO IN ASSESSMENT OF ANTIHY PERTENSIVE ACTIVITY OF 3 BETA-ADRENOBLOCKERS BY 24-HOUR BLOOD-PRESSURE MONITORING/

Citation
Vi. Metelitsa et al., TROUGH PEAK RATIO IN ASSESSMENT OF ANTIHY PERTENSIVE ACTIVITY OF 3 BETA-ADRENOBLOCKERS BY 24-HOUR BLOOD-PRESSURE MONITORING/, Kardiologia, 35(12), 1995, pp. 22-26
Citations number
11
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
ISSN journal
00229040
Volume
35
Issue
12
Year of publication
1995
Pages
22 - 26
Database
ISI
SICI code
0022-9040(1995)35:12<22:TPRIAO>2.0.ZU;2-1
Abstract
The degree and evenness of antihypertensive effects of beta-adrenobloc kers bisoprolol, propranolol and metoprolol were investigated by 24-ho ur blood pressure monitoring in a placebo controlled randomized double blind study. Bisoprolol produced most pronounced and even (sustained) antihypertensive effect throughout 24 hours (trough/peak ratio 91.2). Trough/peak ratio is an independent pharmacodynamic characteristics o f an antihypetensive agent as this ratio can be unrelated to total mag nitude of drug effect during period of investigation.