DIRECT HPLC SEPARATION OF INDENOLOL ENANTIOMERS USING A CELLULOSE CHIRAL STATIONARY-PHASE

Authors
ABOULENEIN HY SERIGNESE V
Citation
Hy. Aboulenein et V. Serignese, DIRECT HPLC SEPARATION OF INDENOLOL ENANTIOMERS USING A CELLULOSE CHIRAL STATIONARY-PHASE, Journal of liquid chromatography & related technologies, 19(6), 1996, pp. 933-938
Citations number
6
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Journal of liquid chromatography & related technologies → ACNP
ISSN journal
10826076
Volume
19
Issue
6
Year of publication
1996
Pages
933 - 938
Database
ISI
SICI code
1082-6076(1996)19:6<933:DHSOIE>2.0.ZU;2-K
Abstract
Racemic indenolol was resolved into its individual enantiomers by high performance liquid chromatography (HPLC) using a commercially availab le cellulose tris (3,5-dimethylphenyl carbamate) chiral stationary pha se, known as Chiralcel OD. Indenolol contains two positional isomers, giving it a total of four enantiomers. The enantiomeric ratio was vali dated and peak identification for each enantiomer was established acco rding to their optical rotation sign.