DISPLACEMENT THIN-LAYER CHROMATOGRAPHY OF MORPHINE AND ITS SEMISYNTHETIC DERIVATIVES

Morphine and its sixteen semisynthetic derivatives of pharmacological interest were subjected to planar chromatography. Adequate stationary and mobile phases for both elution and displacement chromatography wer e found. All these components can be separated by elution mode of deve lopment. At the same time, several morphine derivatives can be the mem ber of displacement train. Experiments and results using either straig ht-phase or reverse phase chromatography with both elution and displac ement types of developments are detailed.