TYPES OF CYCLIC-AMP BINDING-PROTEINS IN HUMAN BREAST CANCERS

Total level and type of cyclic AMP binding proteins have been measured in 117 breast cancers. Six major molecular species of binding protein s were detected. The pattern and relative proportion of binding protei ns varied between individual tumours. However, there were highly signi ficant correlations between the expression of different binding protei ns, including positive relationships between 52 and 67 kD proteins, 43 kD and both 39 and 37 kD proteins and inverse correlations between 48 and 52 kD, 37 and 67 kD proteins. The expression of three binding pro teins (48, 43 and 39 kD) was also positively related to total binding whereas that of the remaining three bindings proteins (67, 52 and 37 k D) was negatively correlated with total levels. It may be that differe ntial expression of certain types of binding protein are the underlyin g rationale for our previously published finding that tumours with hig h levels of high binding protein are associated with poor prognosis.