CYTOGENETIC FINDINGS IN A PATIENT PRESENTING SIMULTANEOUSLY WITH CHRONIC LYMPHOCYTIC-LEUKEMIA AND ACUTE MYELOID-LEUKEMIA

A case of simultaneous presentation of B-chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is described. CLL was documente d by bone marrow and peripheral blood lymphocytosis with a typical B-C LL immunophenotype. The diagnosis of AML was supported by the presence of bone marrow and circulating blast cells positive for myeloperoxida se and myeloid-associated markers. Although the immunophenotyping and morphocytochemical studies indicated two different cell populations (m ature B-CLL lymphocytes and myeloblasts), chromosome aberrations commo nly associated with CLL and AML rr ere found simultaneously in the sam e metaphases obtained from unstimulated 24-hour cultures of peripheral blood cells.