T. Tsunoda et al., FORMATION OF HETEROCYCLES BY THE MITSUNOBU REACTION - STEREOSELECTIVESYNTHESIS OF (-ALPHA-SKYTANTHINE()), Tetrahedron letters, 37(14), 1996, pp. 2463-2466
Cyanomethylenetributylphosphorane was shown to mediate the dehydrocycl
ization of diols and amino alcohols to give the corresponding 6-member
ed O- and N-heterocycles in 90% or better yields. Using the reaction a
s a key step, (+)-alpha-skytanthine, a unique mono terpene alkaloid wa
s synthesized stereoselectively. Copyright (C) 1996 Elsevier Science L
td