A PRACTICAL SYNTHESIS OF FREE AND PROTECTED GUANIDINO ACIDS FROM AMINO-ACIDS

Synthesis of protected guanidino acids in one pot reaction is achieved . Amino acids are treated with trimethylsilyl chloride, triethylamine, dicarbobenzoxy-S-methyl isothiourea in dichloromethone followed by re movol of silyl group by treatment with methanol to give the correspond ing carbobenzoxy guanidino acids. Copyright (C) 1996 Elsevier Science Ltd.