SYNTHESIS OF THE C-1-C-10 FRAGMENT OF THE MACROLIDE ANTIBIOTIC NYSTATIN A(1) FROM A CHIRAL BUILDING-BLOCK OBTAINED VIA CHEMOENZYMATIC APPROACH

Authors
BONINI C GIUGLIANO A RACIOPPI R RIGHI G
Citation
C. Bonini et al., SYNTHESIS OF THE C-1-C-10 FRAGMENT OF THE MACROLIDE ANTIBIOTIC NYSTATIN A(1) FROM A CHIRAL BUILDING-BLOCK OBTAINED VIA CHEMOENZYMATIC APPROACH, Tetrahedron letters, 37(14), 1996, pp. 2487-2490
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
14
Year of publication
1996
Pages
2487 - 2490
Database
ISI
SICI code
0040-4039(1996)37:14<2487:SOTCFO>2.0.ZU;2-M
Abstract
a novel synthesis of C-1-C-10 fragment of Nystatin A(1) was accomplish ed: the synthetic sequence utilized, as chiral building block, a prote cted syn 1,3 polyol previously obtained by chemoenzymatic route; The f inal fully protected fragment was then transformed to a known lactone in order to demonstrate the correct relative and absolute configuratio n. Copyright (C) 1996 Published by Elsevier Science Ltd.