Jp. Carpenter et al., DETERMINATION OF DUPLEX-DOPPLER ULTRASOUND CRITERIA APPROPRIATE TO THE NORTH-AMERICAN SYMPTOMATIC CAROTID ENDARTERECTOMY TRIAL, Stroke, 27(4), 1996, pp. 695-699
Background and Purpose The North American Symptomatic Carotid Endarter
ectomy Trial (NASCET) demonstrated the benefit of carotid endarterecto
my for symptomatic patients with greater than or equal to 70% carotid
stenosis. Screening for detection of significant carotid occlusive dis
ease has relied on duplex Doppler imaging. However, traditional duplex
categories (50% to 79%, 80% to 99%) are not directly applicable to NA
SCET. We sought to evaluate duplex criteria for determination of great
er than or equal to 70% carotid stenosis. Methods Duplex scans and art
eriograms of 110 patients (210 carotids), performed within 1 month of
each other, were reviewed by blinded readers. Arteriographic stenosis
was determined by the NASCET method. Duplex measurements of peak systo
lic and end-diastolic velocity (PSV, EDV) were recorded, and ratios of
velocities in the internal and common carotid arteries (ICA, CCA) wer
e calculated. Receiver-operator characteristic (ROC) curves of sensiti
vity, specificity, positive and negative predictive values (PPV, NPV),
and accuracy were determined. Results Interobserver agreement for mea
surement of arteriographic stenosis was ''almost perfect'' (kappa=0.86
). The criteria chosen for detection of greater than or equal to 70% s
tenosis were PSVICA>210 cm/s (sensitivity, 94%; specificity, 77%; PPV,
68%; NPV, 96%; accuracy, 83%), EDV(ICA)>70 cm/s (sensitivity, 92%; sp
ecificity, 60%; PPV, 73%; NPV, 86%; accuracy 77%), PSVICA/PSVCCA >3.0
(sensitivity, 91%; specificity, 78%; PPV, 70%; NPV, 94%; accuracy, 83%
), and EDV(ICA)/EDV(CCA)>3.3 (sensitivity, 100%; specificity, 65%; PPV
, 65%; NPV, 100%; accuracy, 79%). Conclusions We conclude that greater
than or equal to 70% carotid stenosis can be reliably determined by d
uplex Doppler ultrasound. Individual vascular laboratories must valida
te their own results.