In this randomized double-blind clinical study the efficacy of an enzy
me preparation (Wobenzym(R)) was compared with hormone therapy (Lynest
renol) in 29 women with mastopathy. There was a significantly greater
decrease in number of hardenings of the mammary gland after 2 months o
f enzyme therapy than Lynestrenol therapy: improvement in the former g
roup was 100%, in the latter group 78.6%. No significant difference wa
s observed regarding the numbers of lumps, or number and size of cysts
, sensitivity to touch, feeling of tension, spontaneous pain, and pain
on pressure. The efficacy of both medicines is valued as good. Wobenz
ym(R) therapy was tolerated very well. No side effects appeared at all
. Enzyme therapy is an alternative, low-risk therapy for the managemen
t of mastopathy, which does not interfere with the alsready upset horm
onal balance of the patients.