J. Zamoragonzalez et al., CLUSTERING OF METABOLIC DISORDERS AND HYPERINSULINEMIA IN MEXICO-CITY, International journal of obesity, 20(4), 1996, pp. 311-318
OBJECTIVE: To investigate the relationship between fasting insulin con
centrations and several metabolic and anthropometric variables in the
Mexico City population. DESIGN: Cross-sectional, randomized, stratifie
d by age, sex and economically active and inactive. SUBJECTS: 700 heal
thy adults, older than 20 years, 396 males and 304 females. MEASUREMEN
TS: Body mass index, waist to hip ratio, systolic and diastolic blood
pressure, insulin, glucose, triglycerides, total, HDL and LDL choleste
rol and lipoprotein(a). RESULTS: Means for age were 39 +/- 13 years fo
r men and 41 +/- 12 for women (p < 0.05). In males, the mean values of
body mass index, waist-to-hip ratio, systolic and diastolic blood pre
ssure, triglycerides, glucose and LDL-cholesterol: HDL-cholesterol inc
reased significantly with higher insulin levels, A significant inverse
tendency was observed for the mean concentrations of HDL-cholesterol
and lipoprotein(a). Age, total cholesterol and LDL-cholesterol were no
t related to the insulin levels. A similar pattern was observed in wom
en, significance, however, was only obtained for the body mass index,
triglycerides, glucose, HDL-cholesterol and lipoprotein(a). Age-adjust
ed multiple regression analysis showed that insulin was directly and i
ndependently associated to triglyceride levels and inversely with lipo
protein(a) concentrations for both sexes, and with HDL-C, only in male
s. CONCLUSIONS: The prevalence of insulin resistance related metabolic
disorders was high in a random sample of the Mexico City population.
Increased cardiovascular risk factors associated with the insulin resi
stance syndrome were observed with higher insulin levels, and lipoprot
ein(a) was inversely and significantly related to insulin, Preventive
strategies are urgently needed to avoid the already increased incidenc
e of morbidity and mortality associated to atherosclerotic disease.