IS AN ADDITIONAL VACCINATION NECESSARY FOR A SUCCESSFUL 2ND PREGNANCYIN UNEXPLAINED RECURRENT ABORTERS WHO WERE SUCCESSFULLY IMMUNIZED WITH THEIR HUSBANDS LYMPHOCYTES BEFORE THE 1ST PREGNANCY

PROBLEM: Is an additional immunotherapy necessary or not for patients who have obtained successful results after initial immunotherapy? METH ODS: The successive pregnancy outcome was analyzed in 22 patients out of 29 unexplained recurrent aborters who had undergone immunotherapy w ith their husband's lymphocytes according to our previously reported p rotocol (Takakuwa et al., Am J Reprod Immunol Microbiol. 10:1-9, 1986; Takakuwa et al.. Am J Reprod Immunol. 23:37-41, 1990) and had obtaine d successful outcome between January 1983 and December 1989. In additi on, the alteration of blocking antibodies (BAbs), which was evaluated by a one-way mixed lymphocyte culture reaction (MLR) blocking assay be tween the spouses, was analyzed in 26 patients out of 29. RESULTS: Non e of the 22 patients underwent further immunotherapy because a signifi cantly high titer of MLR-BAbs had been detected before the new pregnan cy. In 19 out of the 21 patients (90.5%), pregnancy was successful. CO NCLUSION: Additional immunotherapy is not necessary for patients who h ave obtained successful results after the initial immunotherapy and ar e positive for MLR-BAbs after their first delivery.