Sf. Sharif et al., HUMAN ASTROCYTE PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA, INTERLEUKIN-1-BETA, AND INTERLEUKIN-6 FOLLOWING EXPOSURE TO LIPOPOLYSACCHARIDE ENDOTOXIN, Neurological research, 15(2), 1993, pp. 109-112
The cytokines, tumour necrosis factor (TNF)-alpha, interleukin (IL)-1b
eta, and IL-6, have been found in the human central nervous system.. R
ecent studies have demonstrated that murine astrocytes produce these c
ytokines when induced with lipopolysaccharide endotoxin (LPS). The pre
sent study investigates the kinetics of TNF-alpha, IL-1beta, and IL-6
production by normal adult human astrocytes when exposed to LPS.