MODELING OF INDOMETHACIN AND DICLOFENAC SODIUM BINDING TO THE MOLECULE OF HUMAN SERUM-ALBUMIN

Modelling of the binding of two non-steroidal anti-inflammatory drugs, indometacin (CAS 53-86-1) and diclofenac sodium (CAS 15307-79-6) to t he molecule of human serum albumin is presented. The models are based on the data obtained using difference spectroscopic technique. Specula tions were made concerning the structural properties of the drugs and albumin molecules as well as the type of chemical interactions taking part in the drug-albumin binding. The proposed approach represents a m ore detailed investigation on the mechanism of drug-protein interactio ns.