SYNTHESIS OF A FUNCTIONALIZED SALEN COPPER COMPLEX AND ITS INTERACTION WITH DNA

Authors
ROUTIER S BERNIER JL WARING MJ COLSON P HOUSSIER C BAILLY C
Citation
S. Routier et al., SYNTHESIS OF A FUNCTIONALIZED SALEN COPPER COMPLEX AND ITS INTERACTION WITH DNA, Journal of organic chemistry, 61(7), 1996, pp. 2326-2331
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
61
Issue
7
Year of publication
1996
Pages
2326 - 2331
Database
ISI
SICI code
0022-3263(1996)61:7<2326:SOAFSC>2.0.ZU;2-C
Abstract
An original procedure for efficient synthesis of a functionalized sale n copper complex is reported. The mode of binding to DNA of the salen . Cu-II complex was investigated by viscometry as well as by absorptio n, circular, and linear dichroism spectroscopy. The complex can induce DNA strand breakage in the presence of a reducing agent as revealed b y a plasmid cleavage assay. The spectroscopic and biochemical data ind icate that the salen . Cu-II complex induces single-stranded breaks vi a an interaction within one of the grooves of the double helix.