SEQUENTIAL DEVELOPMENT OF RESISTANCE TO FLUOROQUINOLONES AND ERYTHROMYCIN IN AN ISOLATE OF CAMPYLOBACTER-JEJUNI

A severe episode of Campylobacter jejuni gastroenteritis in a patient with HIV infection was treated with ciprofloxacin and, because of ther apeutic failure, subsequently with roxithromycin. After treatment, C. jejuni was again isolated from feces and shown to be resistant to both drugs. We present molecular evidence of the sequential development of both ty pes of resistance in the patient isolate. To our knowledge, t his is the first case with documented evidence showing sequential emer gence of resistance to fluoroquinolones and erythromycin in a strain o f C. jejuni during treatment.