Background: The age, sex, and ethnic distribution of adolescents who c
ommit suicide is significantly different from that of the general popu
lation. The present study was designed to examine psychiatric risk fac
tors and the relationship between them and demographic variables. Meth
ods: A case-control, psychologic autopsy study of 120 of 170 consecuti
ve subjects (age, <20 years) who committed suicide and 147 community a
ge-, sex-, and ethnic-matched control subjects who had lived in the Gr
eater New York (NY) area. Results: By using parent informants only, 59
% of subjects who committed suicide and 23% of control subjects who me
t DSM-III criteria for a psychiatric diagnosis, 49% and 26%, respectiv
ely, had had symptoms for more than 3 years, and 46% and 29%, respecti
vely, had had previous contact with a mental health professional. Best
-estimate rates, based on multiple informants for these parameters, fo
r suicides only, were 91%, 52%, and 46%, respectively. Previous attemp
ts and mood disorder were major risk factors for both sexes; substance
and/or alcohol abuse was a risk factor for males only. Mood disorder
was more common in females, substance and/or alcohol abuse occurred ex
clusively in males (62% of 18- to 19-year-old suicides). The prevalenc
e of a psychiatric diagnosis and, in particular, substance and/or alco
hol abuse increased with age. Conclusion: A limited range of diagnoses
-most commonly a mood disorder alone or in combination With conduct di
sorder and/or substance abuse-characterizes most suicides among teenag
ers.