URACHAL CARCINOMA AS 2ND PRIMARY NEOPLASM AFTER RADIOTHERAPY OF ENDOMETRIAL CARCINOMA

A case of urachal carcinoma diagnosed as second primary after successf ul treatment of endometrial carcinoma is reported. This urachal carcin oma occurred within a previous radiation field after a latency of only 18 months. Due to the short latency period the occurrence of the urac hal carcinoma was rather coincidential than correlated with the prior radiotherapy. Neither surgery nor chemotherapy including adriamycin an d paclitaxel could control tumor growth. The patient died 14 months af ter diagnosis. Histological examination revealed that the tumor tissue expressed CEA, but serum levels of CEA were not elevated. Estrogen an d progesterone receptors were found to be negative. During tumor progr ession serum levels of CA 125 became elevated.