PROSPECTIVE RANDOMIZED OPEN STUDY BETWEEN CIPROFLOXACIN AND A COMBINATION OF SULFADIAZINE AND TRIMETHOPRIM IN ANTIBIOTIC-PROPHYLAXIS IN CONNECTION WITH TRANSURETHRAL PROSTATECTOMY

A randomized open prospective study with antibiotics was conducted on 398 cases of TURP to compare the efficacy of either 250 mg of ciproflo xacin twice daily (CF) or 500 mg/160 mg of sulfadiazine-trimethoprim t wice daily (ST) in the prevention of urinary and other infection compl ications. The medication was started on the evening preceding the oper ation and continued up to the day following the removal of an indwelli ng catheter. The preoperative risk factors were similar in both groups . The groups did not differ in terms of the duration of the operation, the volume of irrigation fluid or the weight of the resected chips. T he incidence of immediate complications was 26% in the CF group and 20 % in the ST group. All the complications were minor. There were three serious late complications, one intertervertebral discitis and one cox itis in the CF group and one endocarditis in the ST group. The patient with endocarditis died. On the removal of the indwelling catheter on the third postoperative day, bacteriuria was detected in 3% of the pat ients in the CF group and in 9% in the ST group. The difference was st atistically significant (p < 0.05). One month after TURP, bacteriuria was detected in 7% in both study groups. It is concluded that ciproflo xacin may be more effective in preventing immediate urinary tract infe ctions after TURP than a combination of sulfadiazine and trimethoprim. There were three serious late complications. As late as one month aft er TURP, bacteriuria was still diagnosed in about 7% of all patients, which is why post-TURP monitoring of urinary values is important.