V. Srirajan et al., AN EFFICIENT SYNTHESIS OF CIS-3-HYDROXY-4-PHENYL-BETA-LACTAMS - PRECURSOR FOR TAXOL SIDE-CHAIN, Tetrahedron, 52(15), 1996, pp. 5585-5590
Chiral ketene precursors derived from naturally occurring (+)-3-carene
have been used for the synthesis of beta-lactams via the Staudinger r
eaction. The major diastereomer 5a was separated by crystallization an
d converted in very good yield into (3R, 4S)-3-hydroxy-4-phenyl-beta-l
actam, an advanced intermediate towards the taxol side chain. Copyrigh
t (C) 1996 Elsevier Science Ltd