DEVELOPMENT OF A NO-CARRIER-ADDED METHOD FOR F-18 LABELING OF AROMATIC-COMPOUNDS BY FLUORODEDIAZONATION

Authors
KNOCHEL A ZWERNEMANN O
Citation
A. Knochel et O. Zwernemann, DEVELOPMENT OF A NO-CARRIER-ADDED METHOD FOR F-18 LABELING OF AROMATIC-COMPOUNDS BY FLUORODEDIAZONATION, Journal of labelled compounds & radiopharmaceuticals, 38(4), 1996, pp. 325-336
Citations number
10
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
38
Issue
4
Year of publication
1996
Pages
325 - 336
Database
ISI
SICI code
0362-4803(1996)38:4<325:DOANMF>2.0.ZU;2-X
Abstract
To improve the accessibility of [F-18]arylfluorides a method is presen ted using the decomposition of aromatic diazonium salts in the presenc e of [F-18]fluoride. Several p-toluidyldiazonium salts have been synth esized and decomposed in the presence of fluoride. The most useful sal t, idyldiazonium-2,4,6-tri-isopropylbenzenesulfonate, has been used to investigate several parameters influencing the fluorination. No-carri er-added labelling with [F-18]fluoride gave a radiochemical yield of 3 9% [F-18]p-fluorotoluene in a total synthesis time of 78 minutes.