SYNTHESIS OF A CARBON-LINKED CMP-NANA ANALOG AND ITS INHIBITORY EFFECTS ON GM(3) AND GD(3) SYNTHASES

Authors
HATANAKA Y HASHIMOTO M HIDARI KIPJ SANAI Y NAGAI Y KANAOKA Y
Citation
Y. Hatanaka et al., SYNTHESIS OF A CARBON-LINKED CMP-NANA ANALOG AND ITS INHIBITORY EFFECTS ON GM(3) AND GD(3) SYNTHASES, Heterocycles, 43(3), 1996, pp. 531-534
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
43
Issue
3
Year of publication
1996
Pages
531 - 534
Database
ISI
SICI code
0385-5414(1996)43:3<531:SOACCA>2.0.ZU;2-R
Abstract
A carbon-linked analog of cytidine monophospho-N-acetylneuraminic acid (CMP-NANA) was synthesized as the degradation resistant inhibitor for sialyltransferases. The compound is the first example of synthetic CM P-NANA analog that exhibited inhibitory effects on the activity of GM( 3) and GD(3) synthases.