CASE-REPORT - PENICILLIN-RESISTANT PNEUMOCOCCAL MENINGITIS - NAVIGATING A THERAPEUTIC MINEFIELD

Authors
GREENE GS DEMASI R
Citation
Gs. Greene et R. Demasi, CASE-REPORT - PENICILLIN-RESISTANT PNEUMOCOCCAL MENINGITIS - NAVIGATING A THERAPEUTIC MINEFIELD, The American journal of the medical sciences, 311(4), 1996, pp. 180-185
Citations number
67
Categorie Soggetti
Medicine, General & Internal
Journal title
The American journal of the medical sciences → ACNP
ISSN journal
00029629
Volume
311
Issue
4
Year of publication
1996
Pages
180 - 185
Database
ISI
SICI code
0002-9629(1996)311:4<180:C-PPM->2.0.ZU;2-M
Abstract
Pneumococcal meningitis is a common infection in adults for which peni cillin has long been the drug of choice. Optimal treatment has recentl y become controversial, however, owing to an alarming increase in the number of penicillin-resistant isolates. The authors report a represen tative case of meningitis caused by such an organism, and provide a di scussion of the history, mechanisms of resistance, laboratory evaluati on, and treatment of these infections. Guidelines for prevention are a lso reviewed, including a renewed call for utilization of the 23-valen t pneumococcal vaccine.